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Positive results for Curis phase II trial

Tuesday, March 29, 2011

Curis, a drug development company focusing on next-generation targeted small molecule drug candidates for cancer treatment, announced a positive outcome from a pivotal phase II clinical trial conducted by Roche and Genentech, Curis’ collaborator and a wholly-owned member of the Roche Group, of GDC-0449, a first-in-class hedgehog pathway inhibitor, in patients with advanced basal cell carcinoma (BCC).

Genentech reported the study met its primary endpoint of achieving a target overall response rate, showing GDC-0449 shrank advanced BCC tumors in a pre-defined percentage of people in the study. A preliminary safety assessment showed the most common adverse events were consistent with previous experience with vismodegib.

Genentech plans to submit the data from the clinical trial for presentation at a future medical meeting.

Roche said GDC-0449 (also known as RG3616) now has a generic name approved by the World Health Organization, vismodegib.

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